The Gamble House was designed in 1908 by architects Greene & Greene. It was commissioned by David and Mary Gamble, of Cincinnati, Ohio, as a retirement residence.
David and Mary lived in the house until their deaths in 1923 and 1929, respectively. Julia lived in the house until her death in 1943. Cecil Huggins Gamble and his wife Louise Gibbs Gamble lived in the house beginning in 1946 and briefly considered selling it. They soon changed their minds, however, when prospective buyers spoke of pa...